Abstract
Background: Carisoprodol (Somadril®) is a centrally acting skeletal muscle relaxant that is commonly used to treat serious musculoskeletal disorders. Carisoprodol's mechanism of action is unknown and it is often attributed to its active metabolite, meprobamate. Objective: This study aimed to detect histopathological and immunohistochemical changes in the tissues of the splenic pregnant rats treated orally with Carisoprodol (Soma). Method: Thirty pregnant female albino rats were randomly categorized into three groups. The first group was a negative control and administered oral doses of distilled water. The other two groups were administered oral doses of carisoprodol in the distilled water equivalent to 10.8 mg and 21.6 mg/100g body weight/day respectively for 15 days from the 6th day to the 20th day of gestation. Results: Histological and immunohistochemical studies have been performed on the tissue of the spleen to detect histopathological and immunohistochemical changes. Compared to untreated (negative control) and pregnant rats treated with carisoprodol, the treated rats showed numerous histopathological and immunochemical changes. Conclusion: Treatment of pregnant rats with carisoprodol has induced many atrophic changes in the tissue of the spleen in pregnant rats, so the use of this drug during pregnancy should be under strict protection.
Highlights
Muscle relaxants, known as myorelaxants, are a class of chemical compounds that relax the skeletal muscle and are used to minimize the need for anaesthesia and make intubation easier (Vardanyan and Hruby, 2006).Skeletal muscle relaxants can work in both the central and peripheral nervous systems
Histological and immunohistochemical studies have been performed on the tissue of the spleen to detect histopathological and immunohistochemical changes
Compared to untreated and pregnant rats treated with carisoprodol, the treated rats showed numerous histopathological and immunochemical changes
Summary
Skeletal muscle relaxants can work in both the central and peripheral nervous systems. Carisoprodol (Soma), chlorphenesin carbamate (Maolate), and chlorzoxazone are centrally acting skeletal muscle relaxants (Parafon Forte). Dantrolene, atracurium besylate (Tracrium), and decamethonium bromide (Syncurine, C-10) are peripheral-acting relaxants (Plumlee, 2004). Isopropyl-2-methyl-2-propyl-1,3-propanediol dicarbamate) is a muscle-skeletal relaxant that was licenced as an unregulated drug in the United States (US) in 1959 for the treatment of acute and painful musculoskeletal disorders (Patil et al, 2020). Carisoprodol (Somadril®) is a centrally acting skeletal. The first group was a negative control and administered oral doses of distilled water. The other two groups were administered oral doses of carisoprodol in the distilled water equivalent to 10.8 mg and 21.6 mg/100g body weight/day respectively for 15 days from the 6th day to the 20th day of gestation
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