Abstract
Donor brain death and hypothermic ischaemic storage subject the transplanted heart to a series of injuries that may result in primary graft failure. The aim of this study was to assess whether pre-treatment of the donor and recipient with cariporide after donor hormone resuscitation (HR) allowed viable recovery of the transplanted heart after long-term hypothermic storage. A porcine model incorporating donor brain death, static preservation and orthotopic heart transplantation was used. Brain dead donors were managed for 6h using noradrenaline and included HR (methylprednisolone, triiodothyronine, vasopressin and insulin) in the final 3h.
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