Abstract
The general objective of this systematic review article was to describe the care of epistemic bases in the twenty-first century: paradigms of scientific research. Method: The study used an in-depth literature review of the latest research related to the thematic axis of care-care-research in nursing, which included 23 publications in various databases, which went through a process of inclusion and exclusion criteria. Results: The act of caring has evolved considerably, transforming into a multidimensional practice that goes beyond simple physical attention and is immersed in a deep understanding of the emotional and social needs of individuals. In this context, the epistemic bases that support care in the 21st century find their foundation in the paradigms of scientific research in nursing. Conclusion: In the 21st century, nursing care is nourished by an epistemic foundation that recognizes the complexity and individuality of the health experience. Scientific research paradigms in nursing provide the conceptual framework to address care holistically, considering not only the physical, but also the emotional, social, and cultural aspects that influence people's health and well-being. This approach reflects the evolution of nursing towards a more inclusive and human-centred discipline.
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