Abstract
Caregiver input is important in the assessment of depression in Alzheimer disease (AD), but depression and subjective burden can bias this input. In a 12-week, controlled, clinical trial of sertraline in depressed AD patients, authors correlated caregiver mood and subjective burden on several patient mood measures, incorporating varied degrees of caregiver input. Caregiver variables accounted for up to 33% of the variance in patient mood ratings. Caregiver depression and burden decreased regardless of treatment assignment. Caregiver depression and burden affect their rating of AD patients' mood, but the majority of variance is due to patient characteristics.
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