Abstract
Serum testosterone level steadily decreases with ageing [1]. Low testosterone levels in older adults have been associated with increased adverse cardiovascular (CV) events [2-5].
Highlights
Two studies published in 2013 and 2014 gained significant media attention as they showed increased adverse CV events in men receiving testosterone prescriptions [11,12]
Men aged 65 years or older demonstrated approximately two-fold increase in the risk of myocardial infarction (MI) within 90 days after filling their initial testosterone prescription and this risk declined to baseline in 91-180 days after initial testosterone prescription
There was a 33% risk reduction of composite CV end point in ever-treated group in comparison to patients who never received testosterone therapy [20]
Summary
Two studies published in 2013 and 2014 gained significant media attention as they showed increased adverse CV events in men receiving testosterone prescriptions [11,12]. Vigen R et al [11] showed the increased risk of adverse CV events (death, MI and strokes) with use of testosterone therapy in men with low testosterone who underwent coronary angiography in the Veterans Affairs (VA) system between 2005 and 2011 [11].
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