Abstract
Background: Epicardial adipose tissue (EAT) may produce several cytokines contributed to coronary atherosclerosis. EAT was measured by transthoracic echocardiography or 3 dimensional cardiac computed tomography (CT) on previous studies. We aimed to evaluate the correlation between EAT thickness and cardiovascular risk factors in healthy adults. Method: We collected clinical, biochemical information from 469 subjects (371 men and 98 women) who visited our health promotion center. EAT thickness was measured by chest CT on the free wall of the right ventricle. Result: The mean EAT thickness was 2.47 ± 1.64 mm in total of 469 subjects. EAT thickness was significantly correlated to age, weight, body mass index (BMI), total body fat, systolic and diastolic blood pressure, total cholesterol, low density lipoprotein (LDL)-cholesterol, and fasting glucose in men and to age, height, weight, BMI, total body fat, systolic and diastolic blood pressure, triglycerides, C-reactive protein (CRP), and fasting glucose in women. Multivariate analysis showed that age, BMI, systolic blood pressure, fasting glucose were the variables that independently correlated to EAT thickness in men. But there was no significant independent variable in women. Conclusion: In our study, EAT thickness measured with chest CT in healthy individuals correlates with cardiovascular risk factors in men.
Highlights
body mass index (BMI), systolic and diastolic blood pressure, white blood cell count, and triglycerides were higher in male participants than in female participants, whereas C-reactive protein (CRP) and mean epicardial adipose tissue thickness were higher in female participants (Table 1)
BMI: body mass index, SBP: systolic blood pressure, DBP: diastolic blood pressure, TC: total cholesterol, TG: triglycerides, CRP: C-reactive protein, Epicardial adipose tissue (EAT)-T: epicardial adipose tissue thickness. *Data are presented as mean ± SD. †P-value by t-test for sex
The results of the present study show that the epicardial adipose tissue thickness measured with chest computed tomography (CT) in healthy individuals correlates with cardiovascular risk factors in men
Summary
Accurate evaluation of visceral fat mass is very important for identifying patients at high risk of metabolic syndrome and cardiovascular disease. In most previous studies, epicardial adipose tissue was measured using transthoracic echocardiography or 3-D cardiac computed tomography (CT). The present study aimed to measure epicardial adipose tissue using chest CT in healthy adults with no history of cardiovascular disease or chronic disease, and to investigate its correlation with cardiovascular disease risk factors. We aimed to evaluate the correlation between EAT thickness and cardiovascular risk factors in healthy adults. Conclusion: In our study, EAT thickness measured with chest CT in healthy individuals correlates with cardiovascular risk factors in men
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