Abstract
Heart rate and blood pressure were measured in anesthetized rats after the intraperitoneal administration of radioprotective doses of 5-hydroxytryptamine (5-HT), 2-mercaptoethylamine (MEA), 2-aminoethylisothiouronium (AET), and their mixtures. All of the chemicals produced a slowing of the heart rate in most of the animals. Both doses of 5-HT (7 and 14 mg/kg) consistently elicited a marked depressor response. While a low dose of AET (100 mg/kg) had little effect, higher doses (175 and 250 mg/kg) tended to increase blood pressure. On the other hand, low doses of MEA (60 and 120 mg/kg) tended to lower blood pressure, while a high dose (165 mg/kg) produced no significant change. The blood pressure response after the administration of the mixtures of the chemicals appeared to be the resultant effect of the action of each component. The mixture of all three chemicals (7 mg/kg 5-HT, 100 mg/kg AET, 60 mg/kg MEA) elicited the most consistent response in all animals, slowing the heart rate by 20% and decreasing th...
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