Abstract
The cardiovascular responses of normal subjects to intravenous injections of glucagon and glucagon diluent were assessed by noninvasive polygraphic techniques. A blinding procedure, which eliminated observer bias, was used during the reading of tracings. Analysis of group results showed that glucagon provoked uniformly significant (p < 0.001) changes, including increase in heart rate, blood pressure, pressure-rate product, and ejection time index, and decrease in pre-ejection period, mechanical and electromechanical systole, left ventricular ejection time, and the ratio, PEP LVET . The principal results correlated well with those of previous studies of the hemo-dynamic effects of glucagon. The pre-ejection period and its components responded in a bimodal pattern, the significance of which is unclear.
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