Abstract
Fetal sheep responds to H with blood hypertension, bradycardia, and cardiac output redistribution. Since the response to H in fetuses from species that evolved at high altitudes is not fully known, we studied the cardiovascular response to H in chronically catheterized fetal llamas. we determined in 7 fetal llamas (4 post surgery days) arterial gases, mean arterial pressure, heart rate, cardiac output and its distribution (radiolabelled microspheres) basally (50%Sat Hb descending aorta) and after 20 min of H (14% Sat Hb). The results were: X±SEM,*p<0.05 vs basal). Cardiovascular response to hypoxemia in fetal llamas is comparable to that of fetal sheep. However, in contrast to fetal sheep, brain blood flow does not increase and kidney blood flow markedly decreases, which could affect oxygen supply to these organs. This suggest selective mechanisms of adaptation in these territories that could allow them to arrest metabolic function of the cells. FONDECYT89-1080
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