Abstract
The physiological pulsations that drive tissue fluid homeostasis are not well characterized during brain activation. Therefore, we used fast magnetic resonance encephalography (MREG) fMRI to measure full band (0–5 Hz) blood oxygen level-dependent (BOLDFB) signals during a dynamic visual task in 23 subjects. This revealed brain activity in the very low frequency (BOLDVLF) as well as in cardiac and respiratory bands. The cardiovascular hemodynamic envelope (CHe) signal correlated significantly with the visual BOLDVLF response, considered as an independent signal source in the V1-V2 visual cortices. The CHe preceded the canonical BOLDVLF response by an average of 1.3 (± 2.2) s. Physiologically, the observed CHe signal could mark increased regional cardiovascular pulsatility following vasodilation.
Highlights
The earliest report of discernible physical reactions in human brain were based on observations by Angelo Mosso in patients with open skull lesions, who showed increased brain pulsatility during performance of cued visual and cognitive tasks (Mosso, 1880)
The correlation analysis showed that the highest within-voxel temporal correlations between BOLDVLF and the cardiovascular hemodynamic envelope (CHe)-contrasts were mostly concentrated within the IC1 area but extending slightly into its margins (Figure 1D)
The correlation coefficient of CHe with BOLDVLF was in the range 0.3–0.4
Summary
The earliest report of discernible physical reactions in human brain were based on observations by Angelo Mosso in patients with open skull lesions, who showed increased brain pulsatility during performance of cued visual and cognitive tasks (Mosso, 1880). The EEG pioneer Hans Berger described from direct interoperative observations of brain surgery patients three predominant brain pulsations during neurosurgical procedures, i.e., the vasomotor (
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