Abstract
I.v. administration of McN-2378 appeared to preferentially increase cerebral blood flow as opposed to systemic (femoral) blood flow in two strains of monkeys. This cerebral vasodilation was not affected by β-adrenergic blockade. In the anesthetized dog, the compound transiently lowered systemic arterial pressure with an associated transient decrease in femoral vascular resistance and increased heart rate. Cardiac output in the anesthetized dog was also transiently elevated. Although the compound contains a nitrile group, there is no evidence to suggest that cyanide release is mediating the cerebral vasolidation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
