Abstract
1. 1. In acute experiments in dogs anesthetized with pentobarbital, pressor responses produced by the i.v. injection of serotonin, noradrenaline and electric stimulation of the sympathetic nerves of the spleen, were registered before the i.v. injection of cianopramine (Ro 11-2465), a potent inhibitor of the uptake of serotonin into 5-HT neurones. 2. 2. Doses of 0.1 to 0.5 mg/kg of the antidepressant did not modify the blood pressure, while these produced a more intensive and prolonged presser response during the i.v. injection of serotonin (p < 0.05), noradrenaline (p < 0.001) and stimulation of the splenic nerves (p < 0.005). 3. 3. These effects resulted from the inhibition of the presynaptic reuptake of monoamines. 4. 4. The i.v. injection of 1–2 mg/kg of cianopramine produced significant hypotension (p < 0.001) with baroreceptor and serotoninergic responses blockade. 5. 5. An induced strong hypertensive dose-dependent effect was observed after the i.v. administration of noradrenaline (+ 82 %) and stimulation of splenic nerves (+ 80 %). 6. 6. Cianopramine did not affect the hypotension produced by carbachol and histamine. 7. 7. The peripheric action of cianopramine showed a higher inhibitory effect on the presynaptic reuptake of noradrenaline than on serotonin.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Progress in Neuropsychopharmacology & Biological Psychiatry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.