Abstract

Decrease of calcium in the cerebrospinal fluid (CSF) raises blood pressure whereas increase of calcium lowers it. Although these phenomena have been known for more than 50 years, precise mechanism has not fully been understood. We hypothesized that the extracellular calcium-sensing receptor (CaSR), originally cloned from bovine parathyroid cells, may participate in the blood pressure (BP)-lowering effect of calcium in the CSF. To test the hypothesis, we examined whether the cardiovascular neurons in the medulla oblongata express CaSR.

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