Abstract
BackgroundWe investigated a practical method to measure peak filling rate (PFR) as an indicator of diastolic function of the left ventricle. Ten adult volunteers underwent cine MR imaging using steady-state free precession (SSFP) and phase contrast (PC) sequences to measure PFR. Two PC image sets were acquired at the mitral valve orifice, and PFR was determined from the set with high true temporal resolution (temporal PC method) or with high spatial resolution (spatial PC method). SSFP images covering the left ventricle were acquired, and a time–volume curve was generated around the peak filling phase. PFR was determined using parabolic curve fitting on the first-derivative curve of the LV time–volume curve.FindingsPFR values estimated by the PC methods correlated well with those estimated by the SSFP method, despite apparent underestimation. The underestimation was smaller for the temporal PC method (12 %) than for the spatial PC method (28 %). Intra- and inter-observer repeatabilities were better for the PC methods than for the SSFP method.ConclusionsPFR measurement by PC imaging with high true temporal resolution is convenient and offers excellent repeatability and acceptable accuracy, indicating suitability for clinical use.
Highlights
We investigated a practical method to measure peak filling rate (PFR) as an indicator of diastolic function of the left ventricle
PFR values estimated by the temporal phase contrast (PC) [r = 0.825, 95 % confidence interval (CI) 0.408–0.957, Fig. 3a] and spatial PC (r = 0.781, 95 % CI 0.299–0.946, Fig. 3b) methods correlated well with those estimated by the steady-state free precession (SSFP) method
Mean PFR estimated by the temporal PC method was 12 % smaller than that estimated by the SSFP method
Summary
We investigated a practical method to measure peak filling rate (PFR) as an indicator of diastolic function of the left ventricle. Ten adult volunteers underwent cine MR imaging using steady-state free precession (SSFP) and phase contrast (PC) sequences to measure PFR. SSFP images covering the left ventricle were acquired, and a time–volume curve was generated around the peak filling phase. Cine cardiovascular magnetic resonance (CMR) imaging using a steady-state free precession (SSFP) sequence has been established as a reliable method for the measurement of LV volume and systolic function (Ichikawa et al 2003; Attili et al 2010; Finn et al.2006).
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