Abstract
Background Although cine magnetic resonance imaging (MRI) is considered the gold standard for evaluation of left ventricular (LV) volumes, mass, and systolic function, assessment of diastolic filling is still challenging. The aim of this study was to assess the impact of LV mass on diastolic function by time-volume curve obtained from cine MRI in patients with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and normal subjects. Methods Cine MRI was performed in 10 healthy controls, 11 HCM patients, and 11 DCM patients. LV end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), LV mass, and LVESV/mass ratio were calculated by tracing endocardial and epicardial borders of LV in 8-10 short axis views. Furthermore, to assess the LV diastolic function, the peak filling rate (PFR), time to PFR (TPF), and first third filling fraction (1/3 FF) were calculated from the first derivative curve of the time-volume curve. Temporal resolution was 30 frames per R-R interval. Results
Highlights
Cine magnetic resonance imaging (MRI) is considered the gold standard for evaluation of left ventricular (LV) volumes, mass, and systolic function, assessment of diastolic filling is still challenging
The aim of this study was to assess the impact of LV mass on diastolic function by time-volume curve obtained from cine MRI in patients with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and normal subjects
Cine MRI was performed in healthy controls, HCM patients, and 11 DCM patients
Summary
Cine magnetic resonance imaging (MRI) is considered the gold standard for evaluation of left ventricular (LV) volumes, mass, and systolic function, assessment of diastolic filling is still challenging. The aim of this study was to assess the impact of LV mass on diastolic function by time-volume curve obtained from cine MRI in patients with dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM) and normal subjects
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