Abstract
Six apparently healthy male buffalo calves aged between 6 months to one year with body weight range of 70 - 140 Kg were used in the present investigation. One animal was used for pilot trial for this group. Five calves were randomly taken into this group. The Eschrechia coli endotoxin infused i/v @5 mg/kg BW/hr for 3 hours to all the animals caused symptoms of restlessness, respiratory distress, snoring, diarrhea, profuse salivation along with the significant fall in systolic, diastolic, pulse and mean arterial venous pressure, hypoproteinemia at 1, 2 & 3 hour and hypoglycemia at 3rd hour i.e., end of endotoxin infusion. Respiration was increased significantly during endotoxin infusion at 2nd & 3rd hour and even afterwards till the end of the observation period i.e. 7 hrs. The treatment with hypertonic saline solution, flunixin meglumine and blood raised (p th, 6th & 7th hour respectively i.e., till the end of the observation period. There was no significant effect on Central Venous Pressure (CVP) and body temperature as measured from rectum.
Highlights
Endotoxemia is a state of high levels of endotoxin in blood circulation
The pathophysiological changes occur during shock as a complex cascade of overlapping events which necessitates the development of a comprehensive protocol for the treatment
While one calf was used for standardization of techniques and pilot trial, 5 apparently healthy male buffalo calves of age group from 6 months to one year with body weight range of 70 - 140 Kg procured from local market were used in the present investigation
Summary
Endotoxemia is a state of high levels of endotoxin in blood circulation. It is a hypovolumic shock which is accompanied by decreased cardiac output and increased systemic vascular resistance. During shock there is substantial morbidity and mortality in cattle especially neonates [1]. Barton (1995) [3] was of view that despite plethora of new information, little progress has been made in the development of specific therapies to combat endotoxemia in clinical settings. The pathophysiological changes occur during shock as a complex cascade of overlapping events which necessitates the development of a comprehensive protocol for the treatment
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