Abstract
Experimental models of human pathology are useful guides to new approaches towards improving clinical and surgical treatments. A systematic search through PubMed using the syntax (shock) AND (trauma) AND (animal model) AND (cardiovascular) AND ("2010/01/01"[PDat]: "2015/12/31"[PDat]) found 88 articles, which were reduced by manual inspection to 43 entries. These were divided into themes and each theme is subsequently narrated and discussed conjointly. Taken together, these articles indicate that valuable information has been developed over the past 5 years concerning endothelial stability, mesenteric lymph, vascular reactivity, traumatic injuries, burn and sepsis. A surviving interest in hypertonic saline resuscitation still exists.
Highlights
It is a truth universally acknowledged that experimental models of human pathology are useful guides to new approaches towards improving clinical and surgical treatments, even though transposition is rarely perfect and often unacceptable
This review intends to cover reports from experimental models relating to the effects of shock and trauma upon the cardiovascular system published during a five-year period which ended on December 31, 2014
I have found that data published during these five years cover some classic areas of investigation, and a number of new lines, such as endothelial integrity and vascular reactivity
Summary
It is a truth universally acknowledged that experimental models of human pathology are useful guides to new approaches towards improving clinical and surgical treatments, even though transposition is rarely perfect and often unacceptable It is the author’s experience after a long life in this field of research that many of the procedures routinely used in the evaluation and treatment of shock stem from work initially performed in the framework of carefully experiments. I have found that data published during these five years cover some classic areas of investigation (e.g., hemorrhagic shock, aortic occlusion, trauma, traumatic brain injury and sepsis), and a number of new lines, such as endothelial integrity and vascular reactivity The concept behind this critical review is to examine these contributions and the manner in which they contribute to our contemporary understanding of shock. I was glad to note that hypertonic resuscitation, to which I contributed during my active research life, is still a subject of interest
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
