Abstract
The short-term and longer-term cardiovascular safety of high daily doses of OROS methylphenidate (MPH) of up to 1.5 mg/kg in 114 adolescents with ADHD is reported from Massachusetts General Hospital, Boston, MA.
Highlights
The short-term and longer-term cardiovascular safety of high daily doses of OROS methylphenidate (MPH) of up to 1.5 mg/kg in 114 adolescents with ADHD is reported from Massachusetts General Hospital, Boston, MA
Small but statistically significant increase in diastolic BP and heart rate were observed at 6 weeks, without further increases up to 6 months’ follow-up
The mean total daily dose of OROS-MPH at 6 weeks was 63.1 +/- 25.0 mg; 50% of subjects were taking >72 mg daily; at month 6 these doses were 67.2 +/- 24.3 mg and >72 mg, respectively
Summary
CARDIOVASCULAR EFFECTS OF LONGER-TERM, HIGH-DOSE OROS METHYLPHENIDATE IN ADOLESCENTS WITH ADHD The short-term and longer-term cardiovascular safety of high daily doses of OROS methylphenidate (MPH) of up to 1.5 mg/kg in 114 adolescents with ADHD is reported from Massachusetts General Hospital, Boston, MA. Small but statistically significant increase in diastolic BP and heart rate were observed at 6 weeks, without further increases up to 6 months’ follow-up. The mean total daily dose of OROS-MPH at 6 weeks was 63.1 +/- 25.0 mg; 50% of subjects were taking >72 mg daily; at month 6 these doses were 67.2 +/- 24.3 mg and >72 mg, respectively.
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