Cardiovascular Effects of Dibutyryl cyclic AMP During Nitrous Oxide Halothane Anesthesia

Abstract

The effects of dibutyryl cyclic AMP (db-cAMP) on cardiovascular hemodyna-mics and changes in blood sugar and serum insulin levels were evaluated in GOF-anesthetized man. Observations were made on 15 patients of both sexes and ranging in age from 24 to 63 yrs who were to undergo surgery. Sixty minutes before induction, each patient was given a moderate dose of atropine as preme-dications. Stroke volume and cardiac output were measured by a Minnesota impedance cardiograph, arterial blood pressure was measured by auscultation, total peripheral resistance was calculated from the mean arterial pressure and cardiac output, the heart rate was obtained from an ECG monitor, blood sugar and serum insulin levels were determined from venous blood, and the insulin-glucose ratio was calculated from the insulin and blood sugar levels. Twenty minutes after GOF anesthesia, 5mg/kg of db-cAMP were injected and its effects were studied for 30 minutes prior to surgery with the following results:1) Db-cAMP increased the heart rate slightly and lowered systolic and diastolic pressure while increasing pulse pressure slightly.2) Both the stroke volume and cardiac output increased after db-cAMP injec-tion.3) Total peripheral resistance decreased remarkably after db-cAMP injection.4) Blood sugar and serum insulin levels both increased remarkably, with a slight increase in the insulin-glucose ratio after db-cAMP administration.