Abstract
COBRA VENOM produces profound cardiovascular changes, and envenomed animals maintained by artificial respiration die of circulatory collapse. Evidence to date suggests that both heart and peripheral vessels are affected. In experiments reported herein, cardiac and peripheral vascular changes produced by venom of Naja naja were studied. The profound fall in blood pressure observed in intact animals after intravenous administration of venom was found to occur from loss of peripheral resistance and independently of the heart. In addition, venom rapidly and progressively impairs cardiac work capability. <h3>Material and Methods</h3><h3>Effect of Cobra Venom (Naja naja) on Cardiac Function.—</h3> Eight mongrel dogs weighing from 12 to 14 kg were anesthetized with pentobarbital (20 mg per kg) and no other drugs were utilized. Ventilation was maintained by a mechanical respirator, and animals were prepared as shown in Figure 1. Pressure in the resistor was maintained at a constant 110 mm Hg throughout the
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
