Abstract
A comparison has been made of the pharmacologic properties of toxins isolated from Chiropsalmus quadrigatus and Chironex fleckeri. The effects of the toxins were studied in intact anaesthetized animals and in a number of isolated organ preparations. Toxin extracted from Chiropsalmus tentacle was found to resemble the previously reported Chironex cardiotoxin. However, it was less stable and its activity differed in onset and duration of effects. Toxin from Chiropsalmus caused an initial hypertensive response in animals due to direct vasoconstriction. This was followed by hypotension and cardiac irregularities. Arterial pressure oscillations were frequently seen prior to death. It was not possible to elicit a carotid occlusion reflex during the action of the toxins. Ganglion blocking drugs prevented oscillations by blocking the efferent arm of the vasomotor reflex arc. A stinging by either cnidarian should produce similar symptoms, but Chironex appears the more dangerous species for man.
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Schedule a callMore From: Toxicon : official journal of the International Society on Toxinology
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