Abstract

Background and Aims : Homocysteine (Hcy) has been considered a risk factor for cardiovascular disease (CVD), such as atherosclerosis, stroke, aortic aneurysm. Hyperhomocysteinemia (HHcy) can lead to different pathological conditions, including inflammation, and CVD. Considering the role of arachidonic acid (AA) metabolism in inflammation and vascular homeostasis we aim to investigate the clinical significance of eicosanoids in hyperhomocysteinemia, particularly in Hcy-induced vascular disease through a systematic review of existing studies.

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