Abstract

Recent reports on tetraethylthiuramdisulfide (antabuse®) therapy of alcoholism have stressed the fact that the presence of myocardial failure or coronary disease 1 should make the physician hesitate before instituting this type of therapy; yet only one of these reports 1c describes any severe cardiac effects that may be encountered. It is generally stated or implied that during a tetraethylthiuramdisulfide-alcohol reaction is an increased cardiac output and therefore an increase in cardiac work, 1a,b but that there is no serious risk of too heavy a load on the heart. 2 It was recognized early that after the initial rise in pulse rate to 120-140 that is associated with a fairly stable blood pressure might be a considerable fall in blood pressure occurring from 30 to 60 minutes after ingestion of alcohol in a patient receiving tetraethylthiuramdisulfide, 3 although fully developed collapse was never seen. Electrocardiographic changes have been reported,

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