Abstract
Seven cases are presented in whom cardiac arrhythmias, myocardial failure, or conduction disturbances or significant electrocardiographic changes occurred during prolonged administration of phenothiazines and related compounds, imipramine and amitriptyline. A 29-year-old man developed recurrent biventricular congestive heart failure after prolonged phenothiazine and imipramine administration. Myocardial biopsy material examined in the electron microscope revealed structural abnormalities of mitochondria suggesting a metabolic basis for the cardiomyopathy.
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