Cardiovascular characteristics of patients initially diagnosed breast cancer

Zhaoying Dong,Siyu Chen,Tao Xu,Zhaojun Liu,Xiaoli Zhou,Jun Xiao,Fan Zhang,Changhong Zhang,Qiaojuan Huang

doi:10.1186/s13019-021-01608-6

Abstract

ObjectiveWe aimed to explore the cardiovascular characteristics of patients who were initially diagnosed with breast cancer.MethodsA total of 600 patients who were diagnosed with primary breast cancer were included in this retrospective study. The data of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, lipoprotein (a) (LP (a)) and serum uric acid were collected. Univariate analysis was used to evaluate the cardiovascular risk factors (CVRFs) in patients with breast cancer. The arteriosclerotic cardiovascular disease (ASCVD) risk assessment was performed. Multivariate analysis was used to identify the factors that influenced axillary lymph node metastasis (ALNM).ResultsCompared with the premenopausal group, the prevalence of overweight/obesity (47.6% vs. 35.2%), diabetes (12.8% vs. 4.3%) and hypertension (49.7% vs. 26.3%) were significantly increased in the postmenopausal group (p < 0.05). Comparisons of rural patients and urban patients showed that there were significant differences in the diagnostic age (49.94 ± 9.92 vs. 52.59 ± 11.13) in the rural patients was notably younger in comparison with the urban patients (p < 0.05). However, the number of menopausal patients (44.3% vs. 53.3%) in the rural group were decreased in comparison with the urban group (p < 0.05). In ASCVD risk stratification, the proportion of low-risk patients (56.4% vs. 90.8%), medium-risk patients (20.6% vs 0.3%) and high-risk patients (19.3% vs. 6.6%) were significantly different between the postmenopausal group and premenopausal group (p < 0.05). Residence (OR 0.735; 95% CI 0.516–1.046; p = 0.087), the number of children (OR 1.250; 95% CI 0.990–1.578; p = 0.061) and LP (a) of ≥ 500 mg/L (OR 0.603; 95% CI 0.342–1.063; p = 0.080) were independent influencing factors of ALNM.ConclusionPostmenopausal patients have more CVRFs and higher risks of ASCVD than premenopausal patients initially diagnosed with breast cancer. There was a correlation between CVRFs and ALNM in patients with breast cancer.

Highlights

Breast cancer is the most common malignant tumor among women worldwide
It is necessary to know the combination of cardiovascular risk factors (CVRFs) in patients with breast cancer diagnosed for the first time
The insulin/insulin receptor (IR) signaling pathway plays an important role in breast cancer progression by stimulating the RAS/RAF/MAPK kinase/ ERK cascade in breast tissues, which results in tumor cell proliferation, survival and migration [20, 21]

Summary

Introduction

CVD has become the main cause of death in breast cancer patients [5]. The patients with breast cancer who have cardiovascular risk factors (CVRFs) are more likely to develop drug-related cardiovascular problems after chemotherapy with anthracycline [7]. Radiotherapy and chemotherapy significantly increased the incidence of CVD and mortality of patients with breast cancer [8]. There are many problems in most studies on CVRFs of patients with breast cancer at home and abroad, such as a lack of clinical data and incomplete data acquisition. It is difficult to comprehensively analyze CVRFs of patients with breast cancer. The purpose of this study was to investigate the CVRFs and arteriosclerotic cardiovascular disease (ASCVD) risk assessment in patients initially diagnosed breast cancer in Southwest China

Methods

Results

Discussion

Conclusion