Abstract
Cardiovascular Autonomic Dysfunction and Falls in People With Multiple Sclerosis: Is There a Link? An Opinion Article.
Highlights
Falls and fall-related injuries are highly prevalent in people living with multiple sclerosis (MS)
Multiple sclerosis (MS) is characterized by damage to the central nervous system (CNS) as a result of inflammatory demyelination and neurodegeneration (Ghasemi et al, 2017). While such damage often translates into impairments of cognition and motor function, which are reasonably recognized as the main determinants of falls (Gunn et al, 2013), a growing body of research has explored the relationship between MS-related CNS damage and autonomic dysfunction (Racosta et al, 2015; Findling et al, 2020)
Several observational studies found that brainstem (Habek et al, 2016), midbrain (Saari et al, 2004), hippocampal (Winder et al, 2019), and spinal cord lesions were associated with indices of cardiovascular dysfunction including reduced heart rate variability (HRV) and increased blood pressure variability
Summary
Received: 27 September 2020 Accepted: 18 November 2020 Published: 07 December 2020. Citation: Zanotto T, Hernandez ME, Medrano CN, Wilund KR and Sosnoff JJ (2020) Cardiovascular Autonomic Dysfunction and Falls in People With Multiple Sclerosis: Is There a Link? An Opinion Article. Received: 27 September 2020 Accepted: 18 November 2020 Published: 07 December 2020
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