Abstract
SummaryThe effects of 5 members of the morphinan series have been studied on the electroencephalogram, electrocardiogram and blood pressure of the dog. Levorphan produced maximum central effects with mild cardiovascular depression. Dextrorphan produced severe cardiovascular depression with little or no direct central effect. Levomethorphan and dextromethorphan had mild central and peripheral actions. Levallorphan, which had little action by itself, antagonized both the central and peripheral effects of levorphan.
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