Abstract
The purpose of this study was to evaluate the cardiovascular and autonomic changes induced by high salt intake in fructose‐fed rats. Male Wistar rats (50–60g) were divided into 4 groups (N=10) and followed during 8 weeks: Control (CG); Salt intake (SG;1% NaCl solution during 10 days); Fructose (FG; 10% fructose in drinking water for 8 weeks) and Fructose and salt intake (FSG). Blood pressure variability (BPV) and low frequency spectral oscillations were measured using autoregressive spectral analysis. The fructose overload induced an increase in fasting glycemia in FG and FSG compared to SG and CG. The SG (115 +/− 2 mmHg), FG (117 +/− 6 mmHg) and FSG (112+/− 1 mmHg) presented increased arterial pressure compared to CG (103 +/− 2 mmHg). No changes in heart rate were observed. BPV was increased in SG (17 +/− 2 mmHg2), FG (39 +/− 7 mmHg2) and FSG (15 +/− 5 mmHg2) compared to CG (8.5 +/− 1 mmHg2) and its low‐frequency domain suggesting an increase in sympathetic modulation to the vasculature in experimental groups. These data suggests that salt intake (1% during 10 days) did not change the cardiovascular and autonomic alterations induced by fructose overload.
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