Abstract
Aim: To assess the cardiovascular risk factors and carotid intima media thickness in young Indian PCOS patients. Materials and Methods : The study group included 25 PCOS patients who were diagnosed according to Rotterdam criteria and 15 ealthy controls who had normal menstrual cycles. The mean age and BMI in PCOS (age-22.33years, BMI 28.15.4 kg/m2) and ontrol (age 21.50.6yrs, BMI22.33.7kg/m2). In all these patients detailed clinical examination and anthropometry including height, eight were taken and BMI was calculated. Fasting blood glucose and serum insulin, lipids, high sensitivity C-reactive rotein (hs- CRP), follicle stimulating hormone, luteinising hormone, thyroid stimulating hormone, total testosterone were tested. OMA-IR was calculated according to formula FPG (mmol/l)* S. insulin (mIU/ml)/22.5. Carotid intima media thickness was easured n either side or mean of three readings taken as final value. Results : Carotid intima media thickness was statistically significantly increased in PCOS patients compared to controls 0.6990.06 vs0.5580.05mm, p Conclusion: Present study shows that patients with PCOS are at increased risk of atherosclerosis in young Indian women. Keywords: PCOS CIMT and hsCRP.
Highlights
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting 6-10% of women in the reproductive age group. 1,2 It is characterized by chronic anovulation, hyperandrogenism and or polycystic ovaries
BMI and waist circumference were significantly higher in PCOS patients compared to controls whereas no difference with regard to SBP or DBP
The present study showed that in young PCOS patients from India, CIMT was significantly higher even after accounting for body weight, waist circumference (WC) and insulin resistance
Summary
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting 6-10% of women in the reproductive age group. 1,2 It is characterized by chronic anovulation, hyperandrogenism and or polycystic ovaries. Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting 6-10% of women in the reproductive age group. PCOS is associated with cardiovascular risk factors including dysglycemia, hypertension, hyperinsulinemia and dyslipidemia. This might substantially increases cardiovascular risk in patients with PCOS. A long term study which followed CVD in 780 PCOS women for 22 years did not show increased deaths due to CVD. 3 Meta-analysis by de Groot et al showed that women with PCOS had two times the relative risk of coronary artery disease or stroke.[4] There were few studies assessing the atherogenic risk in patients with PCOS in Indian women and others. Present study aims to assess the carotid intima medial thickness and atherogenic profile including hsCRP which is an inflammatory marker
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