Abstract
After Alzheimer, Parkinson disease (PD) is the most frequently occurring progressive, degenerative neurological disease. It affects both sympathetic and parasympathetic nervous systems in a variable fashion. Cardiovascular symptoms are present in almost all stages of PD and narrower heart rate variability is the earliest sign. Administration of Levodopa to PD patients has proven to provide some degree of neurological protection. This drug, however, causes side effects including nausea and vomiting, lessened by the administration of domperidone. Autopsies in PD patients led some researchers to suggest the involvement of the ventricular arrhythmia induced by domperidone. The aim of the present study was to determine the impact of the adjusted human maximal dose of domperidone, on cardiological features of Wistar rats. domperidone was administered to both 6-hydroxydopamine Parkinsonism models and regular Wistar rats. Quantitative analysis of ranges of heart beat variation showed significant abnormal distribution in both groups receiving domperidone as compared with respective sham counterparts. However, qualitative analysis of Poincaré plots showed that 6-hydroxydopamine Parkinsonism models receiving domperidone had the narrowest full range of heart beat and the worst distribution heart beat ranges as compared with all study groups corroborating with previous suggestion that domperidone administration to PD patients is likely to play a role in sudden unexpected death in this group of patients.
Highlights
Parkinson disease (PD) is the second most frequently occurring progressive degenerative neurological disease
PD patients die from different causes including aspiration pneumonia, dementia, old age, cancer, cardiovascular disease and sudden unexpected death[21,22,23]
Several studies have shown that changes in cardiac function may be present in PD patients[12,24]
Summary
Parkinson disease (PD) is the second most frequently occurring progressive degenerative neurological disease. Domperidone, a drug with primary peripheral nervous involvement, produces an antiemetic action by blocking the dopamine2-receptors (D2) in smooth muscles, reducing levodopa’s excitatory effects on the musculature of the gastrointestinal tract responsible for nausea, reflux and vomiting[17,18]. The direct analysis of electrocardiographs is a time consuming task, but an alternative method adapted to computer processing can overcome this drawback It is the analysis of heart rate variability (HRV), a tool of choice among biomedical researchers[19] The effects of D2 antagonist on cardiac autonomic modulation have been previously suggested in healthy humans using HRV, through sympathetic nervous system stimulation[20]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
