Abstract
Cardiotrophin-1 is newly discovered chemokin with a lot of functions. Aim of our work was to describe most important of them. systematically scan of available scientific resources. Cardiotrophin-1 stimulates the proliferation of cardiomyocytes. Cardiotrophin-1 expression and plasma values are elevated in individuals with heart failure and have high diagnostic efficacy for the heart failure. Plasma values are also an independent prognostic factor. Preliminary findings suggest that the determination of plasma cardiotrophin-1 may be useful for the follow-up of hypertensive heart disease in routine clinical practice. Cardiotrophin-1 also plays an important cardioprotective effect on myocardial damage, is a potent regulator of signaling in adipocytes in vitro and in vivo and potentiates the elevation the acute-phase proteins. Cardiotrophin-1 may play also an important protective role in other organ systems (such as hematopoietic, neuronal, developmental). Cardiotrophin is a newly discovered chemokin with a lot of system effects and is stable in system circulation hence permitting its development in the routine clinical investigation.
Highlights
Cardiotrophin-1 (CT-1) is recently discovered substance which affected most of organ systems
Analysis of the subsequent activation events revealed that CT-1 induces and utilizes Jak1, Jak2, and Tyk2-associated tyrosine kinases, which are in turn relayed by STAT-3 transcription factor and MAPK (ERK1 and -2) signaling Removal of N-linked carbohydrates from the protein backbone of the alpha component resulted in a protein of 45 kDa. These results provide evidence that the CT-1 receptor is composed of a tripartite complex, a situation similar to the high affinity receptor for ciliary neurotrophic factor[15]
According to stepwise multivariate analyses among hemodynamic and neurohumoral factors, a high plasma CT-1 level showed an independent and significant positive relationship with a large left ventricular (LV) mass index in patients with Dilated cardiomyopathy (DCM). These results indicate that CT-1 plays an important role in structural LV remodeling in patients with DCM57
Summary
Cardiotrophin-1 is newly discovered chemokin with a lot of functions. Results: Cardiotrophin-1 stimulates the proliferation of cardiomyocytes. Cardiotrophin-1 expression and plasma values are elevated in individuals with heart failure and have high diagnostic efficacy for the heart failure. Preliminary findings suggest that the determination of plasma cardiotrophin-1 may be useful for the follow-up of hypertensive heart disease in routine clinical practice. Cardiotrophin-1 plays an important cardioprotective effect on myocardial damage, is a potent regulator of signaling in adipocytes in vitro and in vivo and potentiates the elevation the acute-phase proteins. Cardiotrophin-1 may play an important protective role in other organ systems (such as hematopoietic, neuronal, developmental). Conclusion: Cardiotrophin is a newly discovered chemokin with a lot of system effects and is stable in system circulation permitting its development in the routine clinical investigation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
