Abstract
A hospital-based drug-information system has been used to extend preliminary work on the incidence of sudden unexpected death in patients with a diagnosis of cardiac disease who had been prescribed amitriptyline. The finding that there were 13 sudden unexpected deaths in a group of 119 amitriptyline patients compared with only 3 in a carefully matched control group confirms the suspicion linking unexpected death with the administration of this tricyclic antidepressant. There were 4 such deaths in a group of 87 patients receiving imipramine compared with 2 in the control group.
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