Abstract
Abstract Blood and heart muscle of uremic patients were found to contain excessive amounts of catechol compounds of probably adreno-sympathetic origin. These findings were roughly paralleled by the presence of anoxic electrocardiographic changes and signs of cardiac failure. The sera of uremic patients displayed specific, strikingly toxic effects on the isolated frog heart and on the heart of the intact rabbit. Analogous effects were reproduced experimentally by various known catechol compounds and in part also by phenols. Both catechol and phenol compounds are believed to participate significantly in the chemical mechanism leading to cardiac failure and death in uremia.
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