Abstract
Abstract: The Cardiotoxic effect of aqueous extract of some indigenous plants is evaluated on American cockroach, Periplaneta Americana Linn as an experimental animal in laboratory conditions. Toxicity of plant extract was determined in terms of LD50 value in the cockroach by tropical application. However, the Cardiotoxic activity was found to be higher in experimental animals as compared to control on exposure to plant extracts and it was dose dependent. Among the plants evaluated Balanites roxburghii Planch, Cestrum nocturnum Linn, Nicotiana tabecum Linn and Sapindus trifoliatus Linn showed highly Cardiotoxic activity causes significant reduction in heart rate. Whereas, Azadirachta indica A. Juss extract shows least activity than remaining experimental plants. This result therefore seems to support the claim that the plant extract contain saponin and glycoside as an active ingredients in them. Keywords: Cardiotoxic, American cockroach, Plant extract, Heart rate, Dose dependent.
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