Abstract
A series of compounds related to 3‐deoxydigitoxigenin was prepared and assayed for inhibition of myocardial Na+, K+‐adenosine triphosphatase. Although the relatively high activity of 3‐deoxydigitoxin was confirmed, the corresponding 3β, 4β‐epoxide and a mixture of 2, 3‐olefins and 3, 4‐olefins were less active. 3‐Deoxy compounds with variations at the 14‐position and the butenolide ring were much less active than the corresponding 3β‐hydroxy analogs. Thus the activity of 3‐deoxydigitoxigenin appears to be particularly susceptible to structural changes elsewhere in the molecule.
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