Abstract
We evaluated cardiorespiratory and hematologic status at birth, and changes in arterial oxygen tension and pH during the first hour of life in 61 prematurely born infants with moderate to severe erythroblastosis fetalis and compared the findings with their subsequent neonatal course. Intrapartum asphyxia was common and often followed by respiratory distress of varying severity. Twenty infants died; all had the idiopathic respiratory distress syndrome and pathologic finding of pulmonary hyaline membrane disease. These complications were related to the interacting effects of prematurity, anemia, hydrops fetalis, and intrapartum asphyxia and, in particular, to delayed recovery from asphyxia as manifested by persistent hypoxemia and acidemia during the first hour of life.
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