Abstract
Background: The objective of this study was to evaluate the role of cardiorespiratory fitness (CRF) on all-cause mortality in prediabetic veterans. Methods: In this prospective cohort study, CRF was calculated from metabolic equivalents (METs) obtained from routine exercise tolerance testing in a cohort of 1,118 prediabetic veterans. Four fitness categories were established: low-fit ( 8.5 METs; > 75th percentile). Date of death was verified from the Veterans Affairs Beneficiary Identification and Record Locator System File. Results: The mean follow-up period was 7.7 years (8,610 person-years) and there were a total of 251 deaths, averaging 29.1 events per 1,000 person-years. An inverse and graded association between CRF and mortality risk was observed (P = 0.002). For every 1-MET increase in CRF, the adjusted mortality was lowered by 13% (hazard ratios (HR) = 0.87; CI: 0.81 - 0.94, P 8.5 METs) compared to least-fit individuals. With increasing incidence of prediabetes as well as diminished response to preventative lifestyle modifications, enhanced CRF should be advocated in prediabetic individuals. J Endocrinol Metab. 2015;5(3):215-219 doi: http://dx.doi.org/10.14740/jem284w
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