Abstract
94 Several studies have shown that both cardiorespiratory fitness (CRF) and body fat mitigate the major modifiable coronary artery disease (CAD) risk factors (RFs); however, data regarding the relative strength of the relationships for CRF with CAD RFs and body fat with CAD RFs are less available. The objectives of this study were to: (a) describe the relationships for CRF with CAD RFs, and body fat with CAD RFs; and, (b) determine if there are significant differences in the strength of the relationship between CRF and CAD RFs compared to the strength of the relationship between body fat and CAD RFs. Comprehensive health examinations were conducted on a group (N = 4,360) of adult Utah men (n = 3,232; 45.9±10.8 years) and women (n = 1,128; 43.8±12.8 years) between 1975 and 1997. Maximal treadmill exercise testing and hydrostatic weighing were used to categorize those with (12% males, 10% females) and without suspected or known coronary heart disease (CHD), into age and sex adjusted CRF and body fat quintiles, respectively. For both males and females, irrespective of CHD status, a consistent inverse relationship across CRF levels, and a direct relationship across body fat levels was observed in the CAD RFs, with the exception of HDL cholesterol, which was directly related to CRF, and indirectly related to body fat. Adjustment for available confounders did not alter the trends of these relationships. Although, canonical correlations were moderate (Rc = 0.48 to 0.53), multiple regression analyses indicated that there were no significant differences in the strength of the relationship between CRF and CAD RFs compared to the strength of the relationship between body fat and CAD RFs (R′2 = 0.31 to 0.44). However, when stratified simultaneously for body fat and CRF, persons in the highest body fat strata with high levels of CRF had CAD RF values that were comparable to their low body fat, low CRF counterparts. These data indicate that enhanced levels of CRF convey protection against elevation in CAD RFs, even in persons who are moderately obese. This may be clinically relevant to health practitioners who must decide on intervention strategies for persons with moderate degrees of obesity and coexisting metabolic derangements like those seen in the insulin-resistance metabolic syndrome. Funded in part by the Union Pacific Foundation and the Deseret Foundation, LDS Hospital
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