Cardiorespiratory disorders in preschool aged children associated with aerogenic impact of benzene, phenol and formaldehyde

Abstract

There was performed an examination of 437 pre-school aged children living in the conditions of the pollution of atmospheric air with benzene, phenol andformaldehyde. Children with the elevated blood content of benzene, phenol andformaldehyde were detected to be diagnosed as having chronic respiratory diseases and asteno-neurotic syndrome by 3 and 1.3 times more often, respectively, in contrast to the reference group. Cardiorespiratory disorders in children with the elevated content of benzene, phenol and formaldehyde are manifested by restrictive and mixed disorders of airway conductance followed by the increase in markers of proliferative cell activity (CA-72-4 and M 20), changes in the electrophysiologicalprocesses in cardiac muscle pronounced by the decreased electric ventricular systole (QT interval) followed by the decline of the content in blood of glutathione-S-transferase, zAMF, nitrogen oxide and the increase in the lipids hydroperoxide level, and creatine phosphokinase activity.