Abstract
Abstract : Respiratory regulation was studied at normal and sub-normal body temperatures. Hypoxia and body temperature were found to operate reciprocally in determining utilization of oxygen in a closed environment. Respiratory and circulatory responses to imposed tracheal obstruction were studied in normothermic and hypothermic anaesthetized animals. These responses were found to be related to the degree of hypoxia which developed rather than to body temperature, per se. Changes in anatomical and physiological dead space were also measured during reduction of body temperature. There were only small changes in respiratory dead space. No significant impairment of gas transport occurred at body temperatures as low as 28 C. Reflex activity was also studied in normothermic and hypothermic animals. Hypo thermic animals retain reflex activity but the magnitude of the responses is less than at normal body temperature. The augmented response to nor-epine-phrine was greater than that for epinephrine during reduction in body temperature to 28 F. Vagal reflexes also operate at body temperatures as low as 28 F.
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