Abstract
We report the results of hemodynamic, exercise, and pulmonary function studies in a group of patients with Fallot's tetralogy and an aortopulmonary shunt of more than 5 years' duration. None of the patients had developed severe pulmonary hypertension or histological evidence of pulmonary vascular disease. Exercise tolerance was always limited, usually by tiredness in the legs rather than dyspnea. The patients with the largest pulmonary flows and pressures had the least drop in arterial oxygen saturation when they were standing and were able to work at the largest loads. The effect of high pulmonary blood flow and pulmonary venous congestion on the lung volumes was similar to that produced by pulmonary congestion in other diseases.
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