Abstract

Background Obesity predisposes to heart failure, particularly in sedentary subjects. Among others, alterations in myocardial substrate metabolism, myocardial triglyceride (MTG) accumulation and lipotoxicity may be involved. MTG is excessive in overt diabetes and related to diastolic dysfunction. In men, exercise training improves MTG, cardiac performance, physical fitness and insulin sensitivity. Given the gender difference in metabolic response to obesity these results cannot be simply extrapolated to women. Thus, it was the objective to explore the relation between cardiorespiratory fitness, cardiac function, and MTG in obese women.

Highlights

  • Obesity predisposes to heart failure, in sedentary subjects

  • myocardial triglyceride (MTG) content was negatively correlated with cardiopulmonary fitness (r=-0.28, p=0.02) in bivariate correlation analysis (Figure 2)

  • In women with prediabetic (c-ISI < 4.5, n=29) vs. normal glucose tolerance (c-ISI > 4.5, n=36), MTG content was higher (0.83±0.30% vs. 0.61 ±0.23%, p=0.002) and cardiac diastolic function was impaired (1.32±0.44 vs. 1.55±0.46, p=0.047)

Read more

Summary

Open Access

Cardiopulmonary fitness, insulin sensitivity and myocardial fat: a CMR/MRS study in obese non-diabetic women. Wolfgang J Utz1*, Sven Haufe, Martin Pofahl, Julius Traber, Friedrich C Luft, Jens Jordan, Jeanette Schulz-Menger. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011

Background
Results
Methods
Conclusions

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.