Abstract
Background Obesity predisposes to heart failure, particularly in sedentary subjects. Among others, alterations in myocardial substrate metabolism, myocardial triglyceride (MTG) accumulation and lipotoxicity may be involved. MTG is excessive in overt diabetes and related to diastolic dysfunction. In men, exercise training improves MTG, cardiac performance, physical fitness and insulin sensitivity. Given the gender difference in metabolic response to obesity these results cannot be simply extrapolated to women. Thus, it was the objective to explore the relation between cardiorespiratory fitness, cardiac function, and MTG in obese women.
Highlights
Obesity predisposes to heart failure, in sedentary subjects
myocardial triglyceride (MTG) content was negatively correlated with cardiopulmonary fitness (r=-0.28, p=0.02) in bivariate correlation analysis (Figure 2)
In women with prediabetic (c-ISI < 4.5, n=29) vs. normal glucose tolerance (c-ISI > 4.5, n=36), MTG content was higher (0.83±0.30% vs. 0.61 ±0.23%, p=0.002) and cardiac diastolic function was impaired (1.32±0.44 vs. 1.55±0.46, p=0.047)
Summary
Cardiopulmonary fitness, insulin sensitivity and myocardial fat: a CMR/MRS study in obese non-diabetic women. Wolfgang J Utz1*, Sven Haufe, Martin Pofahl, Julius Traber, Friedrich C Luft, Jens Jordan, Jeanette Schulz-Menger. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011
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