Abstract
The pharmacologic features of terephthalic acid and its dihydroxamic derivative (WR 74,106) were compared in five animal species. Contrary to previous reports by other workers, terephthalic acid did not prolong the change in the sulfadimethoxine concentration in the blood plasma in rats or rabbits. WR 74,106 also did not influence the sulfadimethoxine concentration in the blood plasma of either species. WR 74,106 exerted chemotherapeutic action against Plasmodium berghei in mice. The lethal doses of terephthalic acid for mice and dogs are larger than those of WR 74,106. In the latter species, the injection of a sublethal amount of either compound progressively stimulated respiration, increased pulmonary resistance and decreased pulmonary compliance. Also in dogs, terephthalic acid produced a fall in aortic blood pressure, but WR 74,106 did not influence blood pressure, cardiac output, or ventricular function. There were no signs of any deleterious effects produced by WR 74,106 on the heart, lungs, and peripheral nervous system in mice, rats, cats, or rabbits.
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