Cardio‐Pulmonary Coupling II: Reduced Stroke Volume Effects on Time Phase Signals′ Combination at Integrative Site in CNS

Abstract

INTRODUCTIONSince 2011 physiology conference, we introduced a New dynamic theory of breathing control: a complex model integrates multi‐systems. Another abstract described reduced left ventricle ejection fraction (EF) decrease the amplitude of arterial O2, CO2 and [H+] oscillations.HYPOTHESISWe assessed the hypothesis that except low EF, reduced Stroke Volume (SV) decrease the combined amplitude of arterial O2, CO2 and [H+] oscillations signals at integrative site due to different time courses blood arrive at chemical sensors.METHODSSmilar to another abstract; reduced SV, which results blood arrive at aorta and carotid body from different SV (time phase difference), was used to calculate the combined magnitudes of PO2 and PCO2 oscillation arrive at integrative site at CNS.RESULTSThe decreased SV (low CO) results the blood arrives at aorta and carotid by different SV, the weak combined signal (magnitude) for next breath at integrative site at CNS. This will results that mean of O2 and CO2 at central chemical sensors is unstable, and then breath control ¡°gain¡± goes up and down. Low SV may result periodic breathing pattern.CONCLUSIONSThe same O2 and CO2 oscillations, reduced SV will via low EF mixed chamber and decreased in combining signal for next breath at integrative site are influenced by different time phase. It is another explanation of Cardio‐Pulmonary Intra‐Coupling.