Cardioprotective efficiency of postconditioning using L-lactate during ischemia-reperfusion of myocardium in young and old rats under conditions of the systemic action in the animal body of the blocker of M-cholinoreactive systems atropine

Abstract

Myocardial protection from ischemic and reperfusion injury is an important task of modern experimental and clinical medicine. This type of damage is a key link in the pathogenesis of the coronary heart disease and, above all, acute myocardial infarction – a socio-economically significant disease that is one of the main causes of disability and mortality of the adult population in the Republic of Belarus.The aim of the study was to elucidate the cardioprotective efficiency of postconditioning (Post) using L-lactate during ischemia–reperfusion of myocardium in young and old rats under the conditions of systemic action in the body of animals of the blocker of M-cholinergic systems atropine.In experiments on rats, it was found that Post using L-lactate has an infarct-limiting effect during ischemia–reperfusion of myocardium in both young and old animals, however, under the conditions of systemic action of atropine (2 mg/kg), this effect was partially preserved only in old rats. Apparently, the activity of peripheral M-cholinergic systems is important in the mechanisms of implementation of the cardioprotective effects of Post using L-lactate in young, but not in old rats.