Abstract
The investigation purpose. N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (ALM-802 compounds) cardioprotective effect has been studied in rat models of subendocardial ischemia caused by isoproterenol and dobutamine. Material and methods. Acute subendocardial myocardial ischemia in anesthetized rats (urethane 1300 mg/kg, i.p.) was caused by infusion of isoproterenol (20 µg/kg/min i.v.) or dobutamine (80 µg/kg/min i.v.). Results. It was shown that in anesthetized rats, isoproterenol and dobutamine caused almost the same ST-segment depression in the II standard ECG lead. The compound ALM-802 (2 mg/kg i.v.), administered 2 minutes before the infusion start of isoproterenol or dobutamine, equally prevented the occurrence of ischemic changes on the ECG. Conclusion. The non-selective beta-adrenomimetic isoproterenol and the selective β1-adrenomimetic dobutamine cause subendocardial ischemia of the same intensity in anesthetized rats. The compound ALM-802 has a pronounced anti-ischemic effect on both models.
Highlights
Cardioprotective effects of compound ALM-802 on subendocardial ischemia models Tsorin IB, Barchukov VV, Vititnova MB, Likhosherstov AM, Mokrov GV, Kryzhanovskii SA FSBI “Zakusov Institute of Pharmacology”, Moscow, Russia
N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (ALM-802 compounds) cardioprotective effect has been studied in rat models of subendocardial ischemia caused by isoproterenol and dobutamine
The compound ALM-802 (2 mg/kg i.v.), administered 2 minutes before the infusion start of isoproterenol or dobutamine, prevented the occurrence of ischemic changes on the ECG
Summary
Мы сочли целесообразным оценить в сравнительном аспекте антиишемические эффекты соединения АЛМ802 на моделях субэндокардиальной ишемии у крыс, вызванной изопротеренолом и добутамином. Изучить в сравнительном аспекте кардиопротективное действие соединения АЛМ802 на моделях субэндокардиальной ишемии у крыс, вызываемой неселективным β-адреномиметиком изопротеренолом и селективным β1-адреномиметиком добутамином. При проведении экспериментов использовали изотонический раствор натрия хлорида (Красфарм, Россия), изопротеренол («Sigma» Германия), добутамин («Sigma», Германия), АЛМ-802
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