Abstract
Myocardial infarction (MI) is an important cause of mortality around the world. Isoproterenol (ISO) is a synthetic catecholamine found to cause toxicity leading to severe stress in the myocardium of experimental animals. The aim of the present article is to investigate cardioprotective activity of astaxanthin against ISO-induced cardiotoxicity in adult rats, in an attempt to understand its mechanism of action, which may pave the way for possible therapeutic applications. Oral administration of astaxanthin at a concentration of 50 and 100 mg/kg b.wt. daily for 58 days showed a significant protection against-induced alteration in plasma and cardiac SOD, GPx, GSH and CAT as well as CK-MB, LDH, ALT and AST activities. In addition, astaxanthin reduced plasma CK-MB, LDH, ALT and AST as well as cardiac MDA and HP levels as compare to control group. In conclusion, astaxanthin renders resiliency against isoproterenol cardiotoxicity due to its antioxidant and free radical scavenging activity that might serve as novel adjuvant therapy with isoproterenol.
Highlights
Catecholamines are produced under stress conditions and are administered in circumstances of cardiac stress to sustain blood pressure and cardiac function in patients
It was given to all groups except the normal one. astaxanthin (50 and 100 mg/kg) were orally given daily for 58 days and the last dose of each was given 1 h before Isoproterenol administration
Values are given as mean ± SD for groups of eight animals each. * Significantly different from normal group at p
Summary
Catecholamines are produced under stress conditions and are administered in circumstances of cardiac stress to sustain blood pressure and cardiac function in patients. It is an important regulator of myocardial contractility and metabolism. Due to the generation of reactive oxygen species (ROS), catecholamines contribute to oxidative stress [1]. ISO undergoes auto-oxidation, which results in the generation of excess amount of electrons [3]. These electrons can reduce oxygen molecules, resulting in the generation of reactive oxygen species (ROS). Based on the results of these references, the effect of astaxanthin on myocardial infarction has been evaluated in the present study
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