Abstract
Objective: to identify the effectiveness of the drug Reamberin in complex intensive threatment of patients with cardiac surgery in heart fibrillation and remodeling of prosthetic heart valves and plastic defects of atrial and ventricular septa. Reamberin according the following protocol: 400 ml in the first 6 hours of the postoperative period as an intravenous drip at a rate of 60—90 drops/min. In group 2 (control group), 26 patients received standard intensive care medication. In addition to standard clinical and laboratory tests during the study following components were quantitavile determined in blood: troponin I, lactate dehydrogenase, creatine kinase, isofractions of creatine kinase MB, transaminases (alanine aminotransferase and aspartate aminotransferase). Results. Treatment of patients from the main group revealed the recovery of functional parametersof the myocardium, improved dynamics of cardiac enzymes and normalization of blood acid-base status. Conclusion. Inclusion in the complex intensive therapy of post#cardiac surgery of the Reamberin in patients experiencing heart fibrillation after the cardiopulmonary bypass followed by electrical defibrillation improved the clinical course of the early postoperative period and reduced the risk of complications and early mortality.
Highlights
IntroductionВпервые описали феномен обратимой постишемической левожелудочковой недостаточности, в дальней шем E
For the cardiac surgery on the heart that included valve replacement and plastic surgery of atrial and ventric ular septa The patients were divided into two groups: the first group — treatment group (TG) (n=35: 21 men and 14 women, mean age 48,4±1,4 years) that received infusion therapy with the «Reamberin» infusion solution
Surgical intervention was carried out on the back ground of fibrillated heart with cardiopulmonary bypass (CB) using alfa STAT methods, temperature was at 28—30°C, duration of the period CB averaged 52.1±1.3 min in the TG and 60,1±1,6 minutes — in the control group (CG)), followed by reduction of hemody namically effective rate through an electrical defibrillation usingthe biphasic defibrillator «DI 03» (Ukraine)
Summary
Впервые описали феномен обратимой постишемической левожелудочковой недостаточности, в дальней шем E. I. Kloner дали данному синдрому определение «оглушение миокарда», под которым понимают обратимую миокардиаль ную дисфункцию в ответ на реперфузию миокар да после восстановления нормального или суб нормального кровотока в коронарных артериях. Гистологическая тяжесть повреждения связана с длительностью периода ишемии [1,2,3,4,5]
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