Abstract
BackgroundM. verticillata (Malvaceae) is a medicinal plant used in the treatment of wounds, boils, and liver injuries. The plant leaf extracts possess anti-inflammatory and antioxidant activities. Doxorubicin (DOX) is a potent chemotherapeutic agent used in the treatment of various cancers, but its clinical use is limited by acute and chronic cardiotoxicity. This study aims to evaluate the possible cardioprotective role of Malva verticillata against doxorubicin-induced cardiotoxicity.MethodThirty-six male albino rats were divided into six groups, (n = 6): G1: normal control (was given 1 ml/kg of NaCl, 0.9%, twice a week IP), G2: cardiotoxic group (was given 1 mg/kg of DOX twice a week IP). G3 and G4 were given 250 mg/kg and 500 mg/kg of M. verticillata, respectively, while G5 and G6: were given 250, 500 mg/kg of M. verticillata PO and 1 mg/kg IP of DOX. for 6 weeks. Total body weight was taken weekly and Heart: body weight ratio was calculated. Blood samples were collected for determination of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK) and Troponin, the hearts were removed and processed for histopathological examination.ResultsM. verticillata showed a significant dose-dependent reduction in the cardiac enzyme levels, LDH, CPK activities, and Troponin levels. The histopathological studies in rat hearts also supported those findings.ConclusionThe present study suggests that M. verticillata may have a novel and worthwhile cardioprotective effect against DOX-induced cardiotoxicity.
Highlights
IntroductionMedicinal plants (fruits, vegetables, medicinal herbs, etc.) are a source for a wide variety of natural products, such as phenols and flavonoids, which are very interesting for their antioxidant properties [1]
Medicinal plants are a source for a wide variety of natural products, such as phenols and flavonoids, which are very interesting for their antioxidant properties [1]
The present study suggests that M. verticillata may have a novel and worthwhile cardioprotective effect against DOX-induced cardiotoxicity
Summary
Medicinal plants (fruits, vegetables, medicinal herbs, etc.) are a source for a wide variety of natural products, such as phenols and flavonoids, which are very interesting for their antioxidant properties [1]. In addition to their ability to act as an efficient free radical scavenger [2], their natural origin represents an advantage of the consumer in contrast to synthetic ones, which their use is being restricted due to their carcinogenicity [3]. The leaves of Malva verticillata are rich in various active constituents, phenols, flavonoid (quercetin), saponin, alkaloid, resin, and tannin that possess antioxidant and anti-inflammatory effects [13]. This study aims to evaluate the possible cardioprotective role of Malva verticillata against doxorubicin-induced cardiotoxicity
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