Abstract
The cardioprotective activity of Erythrina stricta leaves against isoproterenol-induced myocardial infarction was studied. Wistar albino rats were pretreated with leaf extract (200 mg/kg) daily for 28 days. After treatment, isoproterenol (8.5 mg/kg body weight, orally) was injected to rats at an interval of 24 hours for two days to induce myocardial injury. Cardioprotection was investigated by estimating the activities of serum aminotransferase, lactate dehydrogenase and creatinine kinase. Anti-oxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and thiobarbituric acid reactive substances were determined. The activities of serum marker enzymes were increased significantly (p<0.05) in isoproterenol-induced rats. E. stricta leaf extract showed a decrease in serum enzyme levels and increase of antioxidant status. The results were confirmed by histopathological evidences. The present study concludes that E. stricta leaf extract has a prophylactic value in myocardial infarction.
Highlights
Acute myocardial infarction occurs when the blood supply to a part of the heart is interrupted
Erythrina stricta Roxb. (Papilionaceae), a medium sized deciduous tree used for various ailments in Indian system of medicine
The present study was designed to evaluate the cardioprotective effect of ethanol extract of E. stricta leaves in isoproterenol-induced biochemical and histopathological changes using rats
Summary
Acute myocardial infarction occurs when the blood supply to a part of the heart is interrupted. It is the leading cause of death all over the world. Isoproterenolinduced myocardial necrosis is a well established standard model to study the beneficial effect of drugs on cardiac dysfunction (Uma et al, 2008). Isoproterenol causes severe stress in myocardium and necrotic lesion in heart muscle. The plant contains alkaloids and non-alkaloidal constituents (Chopra, 1992). The leaves of the plant are found to possess rich anti-oxidant activity (Asokkumar et al, 2008). The present study was designed to evaluate the cardioprotective effect of ethanol extract of E. stricta leaves in isoproterenol-induced biochemical and histopathological changes using rats
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